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Retatrutide - Eli Lilly and Company

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Drug Profile

Retatrutide - Eli Lilly and Company

Alternative Names: GGG Tri-agonist - Eli Lilly and Company; GLP-1/GIP/glucagon tri-agonist - Eli Lilly and Company; LY-3437943

Latest Information Update: 18 Mar 2026

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At a glance

  • Originator Eli Lilly and Company
  • Developer Eli Lilly and Company; Hudson Biotech
  • Class Analgesics; Antihyperglycaemics; Antirheumatics; Cardiovascular therapies; Hepatoprotectants; Obesity therapies; Peptides; Sleep disorder therapies; Urologics
  • Mechanism of Action Gastric inhibitory polypeptide receptor agonists; Glucagon receptor agonists; Glucagon-like peptide-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Back pain; Cardiovascular disorders; Non-alcoholic fatty liver disease; Obesity; Osteoarthritis; Sleep apnoea syndrome; Type 2 diabetes mellitus
  • Phase II Renal failure

Most Recent Events

  • 15 Feb 2026 Phase-II clinical trials in Obesity in China (SC) (NCT07467447)
  • 24 Jan 2026 Eli Lilly and Company initiates a phase IIIb TRIUMPH-9 trial for Obesity in the US (SC) (NCT07357415)
  • 22 Jan 2026 Eli Lilly and Company plans a phase III TRIUMPH-9 trial for Obesity in Argentina, Canada, USA (SC) in February 2026 (NCT07357415)

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