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Retatrutide - Eli Lilly and Company

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Drug Profile

Retatrutide - Eli Lilly and Company

Alternative Names: GGG Tri-agonist - Eli Lilly and Company; GLP-1/GIP/glucagon tri-agonist - Eli Lilly and Company; LY-3437943

Latest Information Update: 15 Sep 2025

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At a glance

  • Originator Eli Lilly and Company
  • Class Analgesics; Antihyperglycaemics; Antirheumatics; Cardiovascular therapies; Obesity therapies; Peptides; Sleep disorder therapies
  • Mechanism of Action Gastric inhibitory polypeptide receptor agonists; Glucagon receptor agonists; Glucagon-like peptide-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Back pain; Cardiovascular disorders; Obesity; Osteoarthritis; Sleep apnoea syndrome; Type 2 diabetes mellitus

Most Recent Events

  • 10 Sep 2025 Eli Lilly and Company plans a phase III SYNERGY-OUTCOMES trial for Non-alcoholic steatohepatitis in the US, Argentina, Australia, Austria, Belgium, Brazil, Canada, China, Czech Republic, France, Germany, Hungary, India, Italy, Mexico, Romania, South Korea, Spain, Sweden, Taiwan, Ukraine, the UK (SC) (NCT07165028; CTIS2025-522674-36-00)
  • 24 Jun 2025 Eli Lilly and Company plans a phase III TRIUMPH-7 trial for Obesity and Back pain in USA, Canada, Mexico, Argentina and Poland (SC) (NCT07035093)
  • 06 Jun 2025 Phase-I clinical trials in Type 2 diabetes mellitus (Treatment-experienced) in Austria (SC) (NCT06982846) (EUCT2024-518471-63-00)

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