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Retatrutide - Eli Lilly and Company

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Drug Profile

Retatrutide - Eli Lilly and Company

Alternative Names: GGG Tri-agonist - Eli Lilly and Company; GLP-1/GIP/glucagon tri-agonist - Eli Lilly and Company; LY-3437943

Latest Information Update: 28 Nov 2025

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At a glance

  • Originator Eli Lilly and Company
  • Class Analgesics; Antihyperglycaemics; Antirheumatics; Cardiovascular therapies; Hepatoprotectants; Obesity therapies; Peptides; Sleep disorder therapies
  • Mechanism of Action Gastric inhibitory polypeptide receptor agonists; Glucagon receptor agonists; Glucagon-like peptide-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Back pain; Cardiovascular disorders; Non-alcoholic fatty liver disease; Obesity; Osteoarthritis; Sleep apnoea syndrome; Type 2 diabetes mellitus

Most Recent Events

  • 28 Nov 2025 No recent reports of development identified for phase-I development in Obesity in China (SC, Injection)
  • 18 Nov 2025 Eli Lilly and Company plans a phase III TRIUMPH-8 trial for Obesity in United Kingdom and USA (SC) in December 2025 (NCT07232719)
  • 15 Oct 2025 Phase-III clinical trials in Non-alcoholic fatty liver disease in USA (SC) (NCT07165028)

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