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Zamtocabtagene autoleucel - Miltenyi Biomedicine

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Drug Profile

Zamtocabtagene autoleucel - Miltenyi Biomedicine

Alternative Names: Anti-CD20-anti-CD19 CAR T cells; Anti-CD2019 CAR T cells; CAR-20/19-T cells - Miltenyi Biotec; CD20-CD19-targeting CAR T Cells; CD2019-targeting CAR T cells; MB-CART2019.1; zamto-cel

Latest Information Update: 26 Jun 2026

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At a glance

  • Originator Miltenyi Biomedicine
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase III Non-Hodgkin's lymphoma
  • Phase II B-cell lymphoma; Diffuse large B cell lymphoma
  • Phase I/II Multiple sclerosis
  • Phase I Autoimmune disorders
  • Clinical Phase Unknown Malignant melanoma; Precursor cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 11 Jun 2026 Phase-I clinical trials in Autoimmune disorders (Treatment-experienced) in USA (Parenteral) (NCT06708845)
  • 06 May 2026 Miltenyi Biomedicine in collaboration with National Heart, Lung, and Blood Institute and National Cancer Institute plans a phase II FRONTIER trial for Mantle cell lymphoma (Second-line therapy or greater) in September 2026 (IV, Infusion) (NCT07569965)
  • 08 Apr 2026 Phase-I/II clinical trials in Multiple sclerosis (Treatment-experienced) in Germany (IV) (CTIS2024-517601-82-00) (NCT07178431)

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