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Zamtocabtagene autoleucel - Miltenyi Biomedicine

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Drug Profile

Zamtocabtagene autoleucel - Miltenyi Biomedicine

Alternative Names: Anti-CD20-anti-CD19 CAR T cells - Miltenyi Biotec; Anti-CD2019 CAR T cells; CAR-20/19-T cells - Miltenyi Biotec; CD20-CD19-targeting CAR T Cells - Miltenyi Biotec; CD2019-targeting CAR T cells; DALY II USA; MB-CART2019.1

Latest Information Update: 15 Sep 2025

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At a glance

  • Originator Miltenyi Biotec GmbH
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase III Non-Hodgkin's lymphoma
  • Phase II Diffuse large B cell lymphoma
  • Phase I/II Multiple sclerosis
  • Clinical Phase Unknown Malignant melanoma; Precursor cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 30 Jun 2025 Phase-I/II clinical trials in Multiple sclerosis (Treatment-experienced) in Germany (IV) (CTIS2024-517601-82-00)
  • 07 Dec 2024 Efficacy and adverse events data from a phase I trial in Diffuse large B cell lymphoma presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 27 Nov 2024 Miltenyi Biomedicine plans a phase I trial for Autoimmune disorders (Treatment-experienced) (IV, Infusion) (NCT06708845) (M-2024-423)

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