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UNI 494

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Drug Profile

UNI 494

Alternative Names: Nicorandil prodrug - Unicycive Therapeutics; UNI-494

Latest Information Update: 08 May 2025

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At a glance

  • Originator Sphaera Pharma
  • Developer Unicycive Therapeutics
  • Class Small molecules; Urologics
  • Mechanism of Action KATP channel stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Delayed graft function
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Acute kidney injury
  • Preclinical Delayed graft function; Kidney disorders

Most Recent Events

  • 07 Jan 2025 Unicycive Therapeutics completes a phase-I clinical trials in Acute kidney injury (In volunteers) in United Kingdom (PO, Capsule) (EudraCT2022-003223-17)
  • 31 May 2024 Unicycive Therapeutics has patent protection for UNI 494 in USA and Europe
  • 31 May 2024 Unicycive Therapeutics has patents pending for UNI 494 in USA, Japan, China and the World

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