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PRT 543

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Drug Profile

PRT 543

Alternative Names: C-220; PRT-543

Latest Information Update: 13 Feb 2025

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At a glance

  • Originator Prelude Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action PRMT5 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Diffuse large B cell lymphoma; Mantle-cell lymphoma; Myelodysplastic syndromes; Myelofibrosis; Non-small cell lung cancer; Solid tumours

Most Recent Events

  • 07 Dec 2024 Efficacy, pharmacokinetics, pharmacodynamics and adverse events data from the phase I trial in Solid tumours and Haematological malignancies presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 16 Nov 2022 Prelude Therapeutics completes a phase I trial in Acute myeloid leukaemia, Diffuse large B cell lymphoma, Mantle-cell lymphoma, Myelodysplastic syndromes, Myelofibrosis and Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT03886831)
  • 14 Nov 2022 Discontinued - Phase-I for Acute myeloid leukaemia (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO)

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