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NMRA 140

Drug Profile

NMRA 140

Alternative Names: BTRX-140; BTRX-335140; NMRA-140

Latest Information Update: 01 Aug 2022

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At a glance

  • Originator BlackThorn Therapeutics
  • Developer Neumora Therapeutics
  • Class Amines; Antidepressants; Anxiolytics; Behavioural disorder therapies; Fluorinated hydrocarbons; Mood stabilisers; Oxadiazoles; Piperidines; Quinolines; Small molecules
  • Mechanism of Action Opioid kappa receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Major depressive disorder

Most Recent Events

  • 01 Aug 2022 (Drug) is still in phase II trial in Major depressive disorder in USA (PO) (Neumora Therapeutics pipeline, July 2022)
  • 08 Jun 2022 BlackThorn Therapeutics completes a phase II trial in Major depressive disorder in USA (PO) (NCT04221230)
  • 12 Oct 2021 BlackThorn Therapeutics has been acquired and merged into Neumora Therapeutics
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