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Acasunlimab - BioNTech/Genmab

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Drug Profile

Acasunlimab - BioNTech/Genmab

Alternative Names: BNT-311; DuoBody-PD-L1x4-1BB; GEN-1046; PD-L1x4-1BB

Latest Information Update: 18 Oct 2024

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At a glance

  • Originator BioNTech; Genmab
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD137 antigen agonists; Programmed cell death-1 ligand-1 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase II Endometrial cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 10 Oct 2024 Phase-III clinical trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT06635824)
  • 01 Oct 2024 Genmab completes a phase I trial in Solid tumours (Monotherapy, Combination therapy, Second-line therapy or greater, Metastatic disease, Late-stage disease, Inoperable/Unresectable) in Japan (IV) (NCT04937153)
  • 05 Aug 2024 Genmab plans a phase III trial for Non small cell lung cancer (Second line therapy or greater) (IV) in 2H 2024

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