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MRG 003

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Drug Profile

MRG 003

Alternative Names: MRG-003

Latest Information Update: 15 Jul 2025

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At a glance

  • Originator Miracogen
  • Developer Lepu Biopharma; Miracogen
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Immunotherapies; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Nasopharyngeal cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Nasopharyngeal cancer; Squamous cell cancer
  • Phase II Biliary cancer; Gastric cancer; Non-small cell lung cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 15 Jul 2025 Lepu Medical Technology plans phase I MH-Penile-001 trial in Penile Cancer (First-line therapy, Late-stage disease, Metastatic disease and Unresectable, Combination therapy) in July 2025 (IV, Infusion)(NCT07054307)
  • 16 May 2025 Shanghai Miracogen plans a phase III Magic-C002 trial for Nasopharyngeal cancer (Combination therapy, Recurrent, Metastatic disease, Second-line therapy or greater) in China (IV) in may 2025 (NCT06976190)
  • 06 May 2025 Groupe Oncologie Radiotherapie Tete et Cou in collaboration with Lepu Medical Technology plans a phase II IDEAL trial for Head and Neck Squamous Cell Carcinoma (Late-stage disease, Monotheray, Combination therapy) in June 2025 (IV) (NCT06959108 )

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