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Gefurulimab - Alexion AstraZeneca Rare Disease

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Drug Profile

Gefurulimab - Alexion AstraZeneca Rare Disease

Alternative Names: ALXN-1720

Latest Information Update: 07 Nov 2025

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At a glance

  • Originator Alexion AstraZeneca Rare Disease
  • Class Bispecific antibodies; Recombinant fusion proteins; Single-domain antibodies
  • Mechanism of Action Complement C5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myasthenia gravis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Myasthenia gravis
  • No development reported Proteinuria

Most Recent Events

  • 30 Oct 2025 Adverse events and efficacy data from a phase III PREVAIL trial in Myasthenia gravis released by AstraZeneca
  • 28 Jul 2025 No recent reports of development identified for phase-I development in Proteinuria in South Korea (SC, Infusion)
  • 25 Jul 2025 Gefurulimab - Alexion AstraZeneca Rare Disease receives Orphan Drug status for Myasthenia gravis in USA

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