AB 205
Alternative Names: AB-205; AB-205 + HDT-ASCT; AB-205 + mdUCBT; AB-205-L; AB-205-S; AB-207; E-CEL UVEC cells; Engineered human umbilical vein endothelial cells – Angiocrine Bioscience; Universal E-CEL® Cell TherapyLatest Information Update: 05 Aug 2024
At a glance
- Originator Angiocrine Bioscience
- Developer Angiocrine Bioscience; Weill Cornell Medical College
- Class Antineoplastics; Chemoprotectants; Gene therapies; Stem cell therapies
- Mechanism of Action Cell replacements
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
Highest Development Phases
- Phase III Chemotherapy-induced damage
- Phase I/II Gastrointestinal disorders; Leukaemia; Myelodysplastic syndromes
- Phase I Fissure in ano; Rectal fistula; Shoulder injuries
- Research Soft tissue injuries
- Discontinued Sickle cell anaemia
Most Recent Events
- 31 Jul 2024 Phase-I clinical trials in Fissure in ano in USA (Transdermal), before July 2024 (NCT06456073)
- 13 Jun 2024 Weill Medical College of Cornell University plans phase-Ib trial for Fissure in ano in USA (Transdermal, injection) in June 2024 (NCT06456073)
- 24 Jan 2024 Angiocrine Bioscience terminates a phase-III clinical trials in Chemotherapy-induced damage in USA (IV), as interim analysis showed lack of efficacy (NCT05181540)