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MB 104

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Drug Profile

MB 104

Alternative Names: Anti-CS1 chimeric antigen receptor T cell therapy - Mustang Bio; CS1 CAR T; CS1-targeted CAR T cell therapy; MB 104; MB-104 CS1 CAR

Latest Information Update: 12 Apr 2024

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At a glance

  • Originator City of Hope National Medical Center
  • Developer City of Hope National Medical Center; Mustang Bio
  • Class CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Discontinued Multiple myeloma

Most Recent Events

  • 28 Mar 2024 Discontinued - Phase-I for Multiple myeloma (Recurrent, Second-line therapy or greater) in USA (IV)
  • 25 Nov 2022 Phase-I development in Multiple-myeloma(Recurrent, Second-line therapy or greater) is ongoing in USA (IV) (NCT03710421)
  • 14 May 2019 Mustang Bio plans a pivotal phase I/II trial for Multiple myeloma, in 2020 (Mustang Bio's pipeline, June 2020)

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