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Plozasiran - Arrowhead Pharmaceuticals

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Drug Profile

Plozasiran - Arrowhead Pharmaceuticals

Alternative Names: ARO-APOC3

Latest Information Update: 26 Mar 2025

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At a glance

  • Originator Arrowhead Pharmaceuticals
  • Class Antihyperlipidaemics; Small interfering RNA
  • Mechanism of Action APOC3 protein expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hyperlipoproteinaemia type I
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Hyperlipoproteinaemia type I
  • Phase III Hypertriglyceridaemia
  • Phase II Dyslipidaemias

Most Recent Events

  • 18 Mar 2025 Arrowhead Pharmaceuticals plans the phase III SHASTA-5 trial for Hypertriglyceridaemia (SC, Injection), in April 2025 (NCT06880770)
  • 12 Feb 2025 Arrowhead Pharmaceuticals plans a phase III SHASTA-10 trial for Hypertriglyceridemia in March 2025 (SC, Injection) (NCT06822790)
  • 17 Jan 2025 FDA assigns PDUFA action date of 18/11/2025 for plozasiran for Hyperlipoproteinaemia type I

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