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Rapcabtagene autoleucel - Novartis

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Drug Profile

Rapcabtagene autoleucel - Novartis

Alternative Names: Anti-CD19 CAR-T cell therapy - Novartis; Anti-CD19 chimeric antigen receptor T cell therapy - Novartis; YTB-323; YTB323 Anti CD19 chimeric antigen receptor T cell therapy - Novartis

Latest Information Update: 24 Dec 2024

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At a glance

  • Originator Novartis
  • Class Anti-inflammatories; Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase III Diffuse large B cell lymphoma
  • Phase II Myositis; Systemic scleroderma
  • Phase I/II Lupus nephritis; Systemic lupus erythematosus
  • No development reported Chronic lymphocytic leukaemia; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 10 Dec 2024 Phase-II clinical trials in Myositis (Treatment-experienced) in USA, Japan, Israel (Parenteral) (NCT06665256)
  • 28 Nov 2024 Novartis Pharmaceuticals plans a phase I/II trial for Myasthenia gravis (Treatment resistant) in January 2025 (IV) (NCT06704269)
  • 28 Nov 2024 No recent reports of development identified for phase-I development in Chronic-lymphocytic-leukaemia(Combination therapy, Second-line therapy or greater) in Australia (Parenteral, Infusion)

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