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BTX A51

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Drug Profile

BTX A51

Alternative Names: BTX-A51; PHM®-A51 PROTACs

Latest Information Update: 28 Jul 2024

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At a glance

  • Originator Hebrew University of Jerusalem
  • Developer BioTheryX; Edgewood Oncology
  • Class Amines; Antineoplastics; Chlorinated hydrocarbons; Cyclohexanes; Cyclopropanes; Pyrazoles; Pyrimidines; Small molecules
  • Mechanism of Action Casein kinase I inhibitors; Cyclin-dependent kinase 9 inhibitors; Cyclin-dependent kinase-activating kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; Breast cancer
  • Preclinical Liposarcoma
  • No development reported Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Solid tumours

Most Recent Events

  • 28 Jul 2024 No recent reports of development identified for phase-I development in Non-Hodgkin's-lymphoma(Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO)
  • 28 Jul 2024 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO)
  • 21 May 2024 Phase-II clinical trials in Breast cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT04872166)

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