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SL 172154

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Drug Profile

SL 172154

Alternative Names: SIRPα-Fc-CD40L; SL-172154

Latest Information Update: 17 Oct 2024

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At a glance

  • Originator Shattuck Labs
  • Class Antineoplastics; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action CD40 antigen stimulants; CD47 antigen inhibitors; Immunologic cytotoxicity; Phagocyte stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Fallopian tube cancer; Myelodysplastic syndromes; Ovarian cancer; Peritoneal cancer; Squamous cell cancer

Most Recent Events

  • 01 Oct 2024 Discontinued - Phase-I for Acute myeloid leukaemia (Combination therapy, First-line therapy) in Canada, United Kingdom, USA (IV)
  • 01 Oct 2024 Discontinued - Phase-I for Acute myeloid leukaemia (Combination therapy, Second-line therapy or greater) in USA, United Kingdom, Canada (IV)
  • 01 Oct 2024 Discontinued - Phase-I for Acute myeloid leukaemia (First-line therapy, Monotherapy) in Canada, USA, United Kingdom (IV)

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