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SL 172154

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Drug Profile

SL 172154

Alternative Names: SIRPα-Fc-CD40L; SL-172154

Latest Information Update: 18 Jun 2024

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At a glance

  • Originator Shattuck Labs
  • Class Antineoplastics; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action CD40 antigen stimulants; CD47 antigen inhibitors; Immunologic cytotoxicity; Phagocyte stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes; Ovarian cancer
  • No development reported Fallopian tube cancer; Peritoneal cancer
  • Discontinued Squamous cell cancer

Most Recent Events

  • 14 Jun 2024 Updated Efficacy and adverse event data from the phase I/II in Acute Myeloid syndrome and Myelodysplastic syndromes released by Shattuck Labs
  • 10 Jun 2024 SL 172154 receives Orphan Drug status for Acute myeloid leukaemia in USA
  • 14 May 2024 Efficacy and adverse events data from a phase Ia/b trial in Acute myeloid leukaemia and Myelodysplastic syndromes released by Shattuck Labs

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