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Bavunalimab - Xencor

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Drug Profile

Bavunalimab - Xencor

Alternative Names: Anti-CTLA-4/anti-LAG-3 bispecific monoclonal antibody - Xencor; CTLA-4 x LAG-3 - Xencor; CTLA-4xLAG-3 bispecific antibody - Xencor; Pavunalimab; XmAb-22841; XmAb-841

Latest Information Update: 14 Apr 2025

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At a glance

  • Originator Xencor
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD223 antigen inhibitors; Cytotoxic T-lymphocyte antigen 4 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Malignant melanoma; Solid tumours

Most Recent Events

  • 16 Feb 2023 Xencor and ICON complete the phase I DUET-4 trial in Solid tumours (Monotherapy, Combination therapy, Late stage disease, Second-line therapy or greater) in USA (IV) (NCT03849469)
  • 25 Jan 2023 University of California plans a phase Ib/II trial for Malignant melanoma (Late-stage disease, Metastatic disease, Combination therapy, Second-line therapy or greater) in USA (IV) in April 2023 (NCT05695898)
  • 31 Dec 2022 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (IV)

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