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KAR 2618

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Drug Profile

KAR 2618

Alternative Names: GFB-887; KAR-2618; TRPC4/5 inhibitor - Bristol-Myers Squibb

Latest Information Update: 11 Sep 2024

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At a glance

  • Originator Goldfinch Bio
  • Developer Goldfinch Bio; Karuna Therapeutics
  • Class Small molecules; Urologics
  • Mechanism of Action TRPC4 cation channel inhibitors; TRPC5 cation channel inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Diabetic nephropathies; Focal segmental glomerulosclerosis; Lipoid nephrosis
  • Phase I Anxiety disorders; Mood disorders

Most Recent Events

  • 12 Jun 2024 Phase-I clinical trials in Anxiety disorders (unspecified route), prior to June 2024 (Bristol-Myers Squibb pipeline, June 2024)
  • 12 Jun 2024 Phase-I clinical trials in Mood disorders (unspecified route), prior to June 2024 (Bristol-Myers Squibb pipeline, June 2024)
  • 18 Mar 2024 Karuna Therapeutics has been acquired by Bristol-Myers Squibb

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