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Brimarafenib - SpringWorks Therapeutics

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Drug Profile

Brimarafenib - SpringWorks Therapeutics

Alternative Names: BGB 245; BGB-3245

Latest Information Update: 14 Jun 2025

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At a glance

  • Originator BeiGene
  • Developer BeOne Medicines; MapKure
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto-oncogene protein b-raf inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Phase I Colorectal cancer; Pancreatic cancer

Most Recent Events

  • 15 Jan 2025 SpringWorks Therapeutics terminates phase-I/II trial in Solid tumours (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Australia, USA (PO) due to lack of tolerability of Brimarafenib when given in combination of Mirdametinib (NCT05580770)
  • 18 Apr 2024 Phase-I clinical trials in Colorectal cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT06194877)
  • 18 Apr 2024 Phase-I clinical trials in Pancreatic cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT06194877)

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