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Imdusiran - Arbutus Biopharma

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Drug Profile

Imdusiran - Arbutus Biopharma

Alternative Names: AB-729; ARB 270729

Latest Information Update: 05 Aug 2024

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At a glance

  • Originator Arbutus Biopharma
  • Developer Antios Therapeutics; Arbutus Biopharma; Assembly Biosciences
  • Class Amides; Amino sugars; Antivirals; Drug conjugates; Small interfering RNA
  • Mechanism of Action Hepatitis B surface antigen expression inhibitors; Hepatitis B virus replication inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Hepatitis B

Highest Development Phases

  • Phase II Hepatitis B; Hepatitis D

Most Recent Events

  • 01 Aug 2024 Arbutus Biopharma terminates phase IIa IM-PROVE III trial in Hepatitis B (Combination therapy) in Thailand, Spain, Romania, Poland, Georgia, United Kingdom (SC) (NCT06245291)
  • 05 Jun 2024 Updated efficacy, adverse events and immunogenicity data from the phase-IIa IM-PROVE II trial in Hepatitis B presented at the European Association for the Study of the Liver Congress (EASL-2024)
  • 05 Jun 2024 Updated efficacy and adverse events data from a phase IIa trial for Hepatitis B released by Arbutus Biopharma

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