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Inaxaplin - Vertex Pharmaceuticals

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Drug Profile

Inaxaplin - Vertex Pharmaceuticals

Alternative Names: VX-147

Latest Information Update: 17 Feb 2025

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At a glance

  • Originator Vertex Pharmaceuticals
  • Class Small molecules; Urologics
  • Mechanism of Action Apolipoprotein L1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Kidney disorders
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Kidney disorders
  • Phase II Focal segmental glomerulosclerosis

Most Recent Events

  • 10 Feb 2025 Vertex announces intention to submit application for accelerated approval for Kidney disorders in the US
  • 04 Feb 2025 Vertex Pharmaceuticals initiates phase IIb AMPLIFIED clinical trials in Kidney disorders in USA (PO) (NCT06794996)
  • 12 Jan 2025 Vertex Pharmaceuticals plans a phase IIb AMPLIFIED trial for APOL1-Mediated Kidney Disease

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