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GSK 4532990

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Drug Profile

GSK 4532990

Alternative Names: ARO-HSD; GSK-4532990; VSA-006

Latest Information Update: 22 Oct 2025

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At a glance

  • Originator Arrowhead Pharmaceuticals
  • Developer Arrowhead Pharmaceuticals; GSK
  • Class Amino sugars; Drug conjugates; Hepatoprotectants; Small interfering RNA
  • Mechanism of Action HSD17B13 protein expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alcoholic liver disorders; Non-alcoholic steatohepatitis

Most Recent Events

  • 23 Sep 2025 GlaxoSmithKline completes a phase IIa SKYLINE trials in Non-alcoholic steatohepatitis in USA (Parenteral) (NCT06104319)
  • 27 Sep 2024 Phase-II clinical trials in Alcoholic liver disorders in United Kingdom, Turkey, Sweden, Germany, Japan, France, Denmark, Canada, Mexico, Spain, Spain, Italy, South Korea, Australia, USA (Parenteral) (NCT06613698)
  • 27 Sep 2024 GlaxoSmithKline plans a phase II STARLIGHT trial for Alcoholic liver disorders in Australia, Canada, Denmark, France, Germany, Italy, Japan, Mexico, South Korea, Spain, Sweden, Turkey, United Kingdom, and USA (NCT06613698)

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