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Eclitasertib - Denali Therapeutics/Sanofi

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Drug Profile

Eclitasertib - Denali Therapeutics/Sanofi

Alternative Names: DNL-758; SAR-443122

Latest Information Update: 05 Feb 2026

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At a glance

  • Originator Harvard University
  • Developer Denali Therapeutics Inc; Sanofi
  • Class 2 ring heterocyclic compounds; Amides; Anti-inflammatories; Antipsoriatics; Antirheumatics; Oxazepines; Pyridines; Skin disorder therapies; Small molecules; Triazoles
  • Mechanism of Action RIPK1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Cutaneous lupus erythematosus; Psoriasis; Rheumatoid arthritis; SARS-CoV-2 acute respiratory disease; Ulcerative colitis

Most Recent Events

  • 31 Dec 2025 Discontinued - Phase-II for Ulcerative colitis (Treatment-resistant) in USA, Argentina, Chile, China, Czech Republic, France, Germany, Hungary, India, Italy, Japan, Mexico, Netherlands, Poland, Spain, United Kingdom, Georgia, Romania, Slovakia, Bulgaria (PO)
  • 25 Jul 2025 Sanofi completes a phase I bioavailability trial for Ulcerative colitis (In volunteers) in Netherlands (PO) (EudraCT2025-521073-13-00) (CTIS2025-521073-13-00)
  • 11 Jun 2025 Sanofi initiates a phase I bioavailability trial for Ulcerative colitis (In volunteers) in Netherlands (PO) (EudraCT2025-521073-13-00) (CTIS2025-521073-13-00)

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