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Pimicotinib - Abbisko Therapeutics

Drug Profile

Pimicotinib - Abbisko Therapeutics

Alternative Names: ABSK-021

Latest Information Update: 28 Oct 2026

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At a glance

  • Originator Abbisko Therapeutics
  • Developer Abbisko Therapeutics; Merck AG; Sperogenix Therapeutics
  • Class Amides; Antineoplastics; Ethers; Pyrazoles; Pyridines; Pyrrolidinones; Small molecules
  • Mechanism of Action Macrophage colony-stimulating factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Giant cell tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Giant cell tumour of tendon sheath
  • Phase III Solid tumours
  • Phase II Graft-versus-host disease; Pancreatic cancer
  • No development reported Amyotrophic lateral sclerosis

Most Recent Events

  • 26 Oct 2026 Efficacy and safety data from a phase III MANEUVER trial in Giant cell tumour of tendon sheath released by Merck KGaA
  • 30 Jun 2026 Registered for Giant cell tumour of tendon sheath (Late-stage disease, Inoperable/Unresectable) in Canada (PO)
  • 16 Jun 2026 Abbisko Therapeutics plans a phase II NEXPERT trial for Giant cell tumour of tendon sheath(Neoadjuvant therapy) in China (PO) (NCT07707882)

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