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Avipendekin pegol - Nektar Therapeutics

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Drug Profile

Avipendekin pegol - Nektar Therapeutics

Alternative Names: NKTR-255; Polymer-conjugated IL-15 - Nektar Therapeutics

Latest Information Update: 14 Aug 2024

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At a glance

  • Originator Nektar Therapeutics
  • Developer AbelZeta Pharma; Fred Hutchinson Cancer Research Center; Gilead Sciences; Janssen; M. D. Anderson Cancer Center; Merck KGaA; Nektar Therapeutics; Stanford University
  • Class Antineoplastics; Antivirals; Immunotherapies; Interleukins; Recombinant fusion proteins
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Interleukin 15 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase II/III B-cell lymphoma; Diffuse large B cell lymphoma
  • Phase II Non-small cell lung cancer; Urogenital cancer
  • Phase I/II Cervical cancer; Colorectal cancer; Squamous cell cancer
  • Phase I Multiple myeloma; Non-Hodgkin's lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma
  • Preclinical Burkitt's lymphoma; Chronic lymphocytic leukaemia; Follicular lymphoma; Triple negative breast cancer
  • Research Viral infections

Most Recent Events

  • 08 Aug 2024 Efficacy data from a phase I trial in B-cell lymphoblastic leukaemia lymphoma released by Nektar Therapeutics
  • 11 Dec 2023 Pharmacodynamics data from a preclinical trial in Burkitt's lymphoma released by Nektar Therapeutics
  • 09 Dec 2023 Updated pharmacodynamics data from a preclinical studies in Burkitt Lymphoma presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-2023)

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