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Vepdegestrant - Arvinas/Pfizer

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Drug Profile

Vepdegestrant - Arvinas/Pfizer

Alternative Names: ARV-471; PF-07850327

Latest Information Update: 13 Jun 2025

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At a glance

  • Originator Arvinas
  • Developer Arvinas; Pfizer
  • Class Antineoplastics; Isoindoles; Phenols; Piperazines; Piperidines; Small molecules; Tetrahydronaphthalenes
  • Mechanism of Action Estrogen receptor degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration HER2 negative breast cancer

Most Recent Events

  • 06 Jun 2025 Preregistration for HER2-negative-breast-cancer (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) in USA (PO)
  • 30 May 2025 Efficacy and adverse events data from a phase III VERITAC-2 trial in Breast cancer released by Arvinas
  • 01 May 2025 Arvinas announces intention to submit NDA to US FDA for HER2-negative-breast-cancer in second half of 2025

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