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Camonsertib - Repare Therapeutics

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Drug Profile

Camonsertib - Repare Therapeutics

Alternative Names: RG-6526; RP-3500

Latest Information Update: 23 Sep 2025

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At a glance

  • Originator Repare Therapeutics
  • Class Antineoplastics; Morpholines; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action ATR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Cancer

Highest Development Phases

  • Phase II Solid tumours
  • Phase I/II Chronic lymphocytic leukaemia; Non-small cell lung cancer

Most Recent Events

  • 05 Sep 2025 Repare Therapeutics in collaboration with National Cancer Institute plans a phase I trial for Head and neck cancer (Combination therapy, Inoperable, Recurrent) (PO) in December 2025 (NCT07156227)
  • 13 Jun 2025 Repare Therapeutics completes phase-I/II clinical trials in Solid tumours (Monotherapy, Combination therapy, Late-stage disease, Second-line therapy or greater, In children, In adolescents, In adults, In the elderly) in US, Denmark, Canada and the UK (PO) (NCT04497116) (EudraCT2020-000301-87)
  • 25 Apr 2025 Efficacy, pharmacodynamics and adverse events data from the MYTHIC phase I trial in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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