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Lunresertib - Debiopharm

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Drug Profile

Lunresertib - Debiopharm

Alternative Names: CCNE1-SL inhibitor - Repare Therapeutics; Lunre; Manchester; RP-6306

Latest Information Update: 19 Sep 2025

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At a glance

  • Originator Repare Therapeutics
  • Developer Canadian Cancer Trials Group; Repare Therapeutics; University Health Network
  • Class Amides; Antineoplastics; Pyridines; Small molecules
  • Mechanism of Action PKMYT1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Solid tumours
  • Phase I Ovarian cancer; Uterine cancer

Most Recent Events

  • 19 Sep 2025 Phase I trial is ongoing for Solid tumours (In adolescents, In adults, In the elderly, Late-stage disease, Metastatic disease, Monotherapy, Combination therapy, Second-line therapy or greater) in Denmark and Canada (NCT04855656)
  • 21 Jul 2025 Lunresertib licensed to Debiopharm worldwide
  • 04 Jul 2025 Repare Therapeutics terminates the phase I MINOTAUR trial in Solid tumours (Combination therapy, Metastatic disease, Late-stage disease, Second-line therapy or greater) in the US, Canada, Spain and the United Kingdom (PO) due to the sponsor decided to terminate the study (NCT05147350)

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