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VLX 1005

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Drug Profile

VLX 1005

Alternative Names: CAD-1005; ML-355; VLX-1005

Latest Information Update: 02 Sep 2026

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At a glance

  • Originator Eastern Virginia Medical School; National Institutes of Health (USA); Thomas Jefferson University; University of California
  • Developer Cadrenal Therapeutics; University of Michigan; Veralox Therapeutics
  • Class Amines; Antihyperglycaemics; Antithrombotics; Benzothiazoles; Small molecules; Sulfonamides
  • Mechanism of Action 12-lipoxygenase inhibitors; Platelet aggregation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Heparin-induced thrombocytopenia and thrombosis syndrome
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Heparin-induced thrombocytopenia and thrombosis syndrome
  • Preclinical Acute kidney injury; Type 2 diabetes mellitus
  • No development reported Type 1 diabetes mellitus

Most Recent Events

  • 02 Sep 2026 Cadrenal Therapeutics announces Type D Meeting feedback with US FDA for phase 3 trial in Heparin-induced thrombocytopenia
  • 28 Jul 2026 No recent reports of development identified for preclinical development in Type-1 diabetes mellitus in USA (PO)
  • 20 Jul 2026 VLX 1005 is available for licensing as of 14 Jul 2026. https://www.cadrenal.com

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