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VLX 1005

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Drug Profile

VLX 1005

Alternative Names: ML-355; VLX-1005

Latest Information Update: 06 Feb 2025

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At a glance

  • Originator Eastern Virginia Medical School; National Institutes of Health (USA); Thomas Jefferson University; University of California
  • Developer University of Michigan; Veralox Therapeutics
  • Class Amines; Antihyperglycaemics; Antithrombotics; Benzothiazoles; Small molecules; Sulfonamides
  • Mechanism of Action 12-lipoxygenase inhibitors; Platelet aggregation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Heparin-induced thrombocytopenia and thrombosis syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Heparin-induced thrombocytopenia and thrombosis syndrome
  • Preclinical Type 1 diabetes mellitus

Most Recent Events

  • 07 Dec 2024 Adverse events and pharmacokinetics data from a phase I DDI trial in healthy volunteers presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-2024)
  • 14 Aug 2024 VLX 1005 receives Orphan Drug status for Heparin-induced thrombocytopenia and thrombosis syndrome in Europe
  • 26 Sep 2023 Phase-II clinical trials in Heparin-induced thrombocytopenia and thrombosis syndrome (In adults) in USA (IV) (NCT05785819)

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