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Englumafusp alfa - Roche

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Drug Profile

Englumafusp alfa - Roche

Alternative Names: CD19 Targeted 4-1BB Ligand - Roche; CD19-4-1BBL - Roche; RG-6076; RO-7227166

Latest Information Update: 01 Dec 2025

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At a glance

  • Originator Roche
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Non-Hodgkin's lymphoma

Most Recent Events

  • 01 Dec 2025 Englumafusp alfa is still in phase I trials for Non-Hodgkin's lymphoma (Combination therapy, Second-line therapy or greater) in Denmark, Australia, Belgium, US, France, Italy, Spain and the UK (Roche's pipeline, December 2025)
  • 28 Aug 2025 No recent reports of development identified for phase-I development in Non-Hodgkin's-lymphoma(Combination therapy, Second-line therapy or greater) in France (IV, Infusion)
  • 28 Aug 2025 No recent reports of development identified for phase-I development in Non-Hodgkin's-lymphoma(Combination therapy, Second-line therapy or greater) in Italy (IV, Infusion)

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