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Debio 0123

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Drug Profile

Debio 0123

Alternative Names: Debio-0123

Latest Information Update: 07 Mar 2025

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At a glance

  • Originator Almac Discovery
  • Developer Almac Discovery; Debiopharm; Repare Therapeutics
  • Class Antineoplastics
  • Mechanism of Action WEE1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Breast cancer; Glioblastoma
  • Phase I Small cell lung cancer; Solid tumours
  • No development reported Cancer

Most Recent Events

  • 17 Jan 2025 Phase-I/II clinical trials in Breast cancer (Metastatic disease, Late-stage disease, Inoperable/Unresectable, Combination therapy, Second-line therapy or greater) in Spain (PO) (NCT06612203)
  • 13 Sep 2024 Updated efficacy and adverse event data from phase I trial in Solid tumours was presented at the 49th European Society for Medical Oncology Congress 2024 (ESMO-2024)
  • 31 May 2024 Efficacy, adverse event and pharmacokinetics data from a phase I trial in Solid tumour presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)

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