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Divesiran - Silence Therapeutics

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Drug Profile

Divesiran - Silence Therapeutics

Alternative Names: SLN-124

Latest Information Update: 03 Nov 2025

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At a glance

  • Originator Intradigm Corporation
  • Developer Silence Therapeutics
  • Class Antineoplastics; Hexosamines; Small interfering RNA
  • Mechanism of Action RNA interference; TMPRSS6 protein expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Beta-thalassaemia; Polycythaemia vera; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Polycythaemia vera
  • No development reported Haemochromatosis; Iron overload; Myelodysplastic syndromes
  • Discontinued Beta-thalassaemia

Most Recent Events

  • 23 Oct 2025 Silence Therapeutics completes enrolment in the phase II SANRECO trial for Polycythaemia vera in Malaysia, Poland, Bulgaria, USA and Australia (SC) (NCT05499013)
  • 28 Aug 2025 No recent reports of development identified for phase-I development in Myelodysplastic-syndromes in Germany (SC, Injection)
  • 28 Aug 2025 No recent reports of development identified for phase-I development in Myelodysplastic-syndromes in Israel (SC, Injection)

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