Anti-BAFF receptor CAR T cell therapy - City of Hope National Medical Centre/PeproMene Bio
Alternative Names: Anti-BAFF-R CAR T therapy; PMB-CT01Latest Information Update: 28 Nov 2025
At a glance
- Originator City of Hope National Medical Center
- Developer City of Hope National Medical Center; PeproMene Bio
- Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
- Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
-
Orphan Drug Status
No
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
- Available For Licensing Yes - B-cell lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma
Highest Development Phases
- Phase I B-cell lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma
Most Recent Events
- 20 Nov 2025 Updated efficacy and adverse events data from a phase I trial in Mantle-cell lymphoma released by PeproMene Bio
- 20 Nov 2025 Efficacy and adverse events data from a phase I trial in Precursor B-cell lymphoblastic leukaemia-lymphoma released by PeproMene
- 30 May 2025 Pharmacodynamics data from a preclinical trial in B-cell lymphoma presented at the 61st Annual Meeting of the American Society of Clinical Oncology (ASCO-2025)