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Anti-BAFF receptor CAR T cell therapy - City of Hope National Medical Centre/PeproMene Bio

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Drug Profile

Anti-BAFF receptor CAR T cell therapy - City of Hope National Medical Centre/PeproMene Bio

Alternative Names: Anti-BAFF-R CAR T therapy; PMB-CT01

Latest Information Update: 24 Dec 2024

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At a glance

  • Originator City of Hope National Medical Center
  • Developer City of Hope National Medical Center; PeproMene Bio
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No
  • Available For Licensing Yes - B-cell lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Highest Development Phases

  • Phase I B-cell lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 20 Dec 2024 PeproMene plans a phase I trial for Follicular lymphoma (Second-line therapy or greater)
  • 07 Dec 2024 Updated efficacy data from a phase I trial in Mantle-cell lymphoma the trial at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 07 Aug 2024 Phase-I development in Precursor-B-cell-lymphoblastic-leukaemia-lymphoma (Second-line therapy or greater) is still ongoing in USA (Parenteral)

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