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Nalmefene - Avior Bio

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Drug Profile

Nalmefene - Avior Bio

Alternative Names: AV-104; TH-104

Latest Information Update: 23 Dec 2024

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At a glance

  • Originator Avior Bio
  • Developer Avior Bio; Tharimmune
  • Class Anti-inflammatories; Antipruritics; Opioid analgesics; Skin disorder therapies; Small molecules
  • Mechanism of Action Interleukin 17 inhibitors; Neurokinin 1 receptor antagonists; Opioid kappa receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Pruritus
  • Phase I Unspecified
  • No development reported Prurigo nodularis

Most Recent Events

  • 17 Dec 2024 Tharimmune plans phase IIa trial for Pruritus (Treatment-experienced), in March 2025 (Transmucosal) (NCT06733519)
  • 06 Nov 2024 Tharimmune completes a phase I absolute bioavailability trial (In volunteers) (Buccal, IV) (NCT06198686)
  • 28 Jan 2024 No recent reports of development identified for phase-I development in Prurigo-nodularis in USA (Transmucosal)

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