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Nrf2 activator - AstraZeneca

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Drug Profile

Nrf2 activator - AstraZeneca

Latest Information Update: 14 Jul 2025

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At a glance

  • Originator C4X Discovery
  • Developer AstraZeneca; C4X Discovery
  • Class Anti-inflammatories; Antianaemics; Small molecules
  • Mechanism of Action NF-E2-related factor 2 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Inflammation

Most Recent Events

  • 28 Nov 2022 AstraZeneca in-license oral Nrf2 activators for development and commercialisation in Chronic obstructive pulmonary disorder in Worldwide
  • 01 Oct 2019 Preclinical trials in Sickle cell anaemia in United Kingdom (PO)
  • 27 Sep 2019 Preclinical trials in Chronic obstructive pulmonary disease in United Kingdom (PO)

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