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AMG 199

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Drug Profile

AMG 199

Alternative Names: AMG-199; MUC17 HLE BiTE®

Latest Information Update: 14 Jun 2025

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At a glance

  • Originator Amgen
  • Developer Amgen; BeOne Medicines
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Gastric cancer; Oesophageal cancer; Solid tumours

Most Recent Events

  • 08 Aug 2023 Discontinued - Phase-I for Gastric cancer in China (IV) (Amgen pipeline, August 2023)
  • 08 Aug 2023 Discontinued - Phase-I for Oesophageal cancer in China (IV) (Amgen pipeline, August 2023)
  • 08 Aug 2023 Discontinued - Phase-I for Solid tumours (In the elderly, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater, In adults) in USA, Taiwan, Spain, South Korea, Netherlands, Japan, Germany, France, Austria (IV) (Amgen pipeline, August 2023)

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