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GSK 4381562

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Drug Profile

GSK 4381562

Alternative Names: anti-PVRIG; GSK-4381562; GSK’562; SRF 813

Latest Information Update: 30 May 2025

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At a glance

  • Originator Surface Oncology
  • Developer GSK
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Natural killer cell stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Squamous cell cancer
  • No development reported Solid tumours

Most Recent Events

  • 13 May 2025 GlaxoSmithKline discontinues a phase II trial in Squamous cell carcinoma of head and neck (Metastatic disease) in USA, Argentina, Brazil, Canada, Denmark, Finland, France, Germany, Greece, Hungary, Italy, Japan, South Korea, Norway, Poland, Portugal, Romania, Spain, Sweden, Taiwan and Turkey due to the results (NCT06062420)
  • 28 Apr 2025 No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy, Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) in Canada (Parenteral)
  • 28 Apr 2025 No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy, Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) in Japan (Parenteral)

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