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Xelafaslatide - ONL Therapeutics

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Drug Profile

Xelafaslatide - ONL Therapeutics

Alternative Names: ONL-1204

Latest Information Update: 04 Apr 2026

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At a glance

  • Originator ONL Therapeutics
  • Class Eye disorder therapies; Peptides; Small molecules
  • Mechanism of Action CD95 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Retinal detachment
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Dry macular degeneration; Retinal detachment
  • Phase I Open-angle glaucoma
  • Preclinical Retinitis pigmentosa

Most Recent Events

  • 16 Mar 2026 Phase-II clinical trials in Dry macular degeneration in Canada (Intravitreous) (NCT06659445), Switzerland (Intravitreous)
  • 09 Dec 2025 Adverse events from a phase Ib trial in Geographic Atrophy (GA) released by ONL Therapeutics
  • 10 Nov 2025 Xelafaslatide is still in phase I development for geographic atrophy (GA) associated with age-related macular degeneration, Retinal detachment and Open-angle glaucoma in Australia and New Zealand

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