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Tobemstomig - Hoffmann-La Roche

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Drug Profile

Tobemstomig - Hoffmann-La Roche

Alternative Names: Anti PD-1 anti LAG-3 bispecific antibody - Roche; Anti PD1 x LAG3; anti-PD-1/Anti-LAG-3 bispecific antibody RO7247669; anti-PD1/anti-LAG3 bispecific antibody RO7247669; PD1-LAG3 BsAb; RG-6139; RO-7247669

Latest Information Update: 28 Jul 2026

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At a glance

  • Originator Roche
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD223 antigen inhibitors; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Liver cancer; Malignant melanoma; Non-small cell lung cancer; Oesophageal cancer; Solid tumours; Triple negative breast cancer; Urogenital cancer

Most Recent Events

  • 30 Apr 2026 Hoffmann-La Roche completes a phase-II clinical trials in Non-small cell lung cancer (First-line therapy, Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in Australia, Belgium, Brazil, Canada, France, Germany, Italy, Mexico, South Korea, Turkey, USA (IV) (NCT05775289) (EudraCT2022-001440-18)
  • 26 Dec 2025 Discontinued - Phase-I/II for Liver cancer (Neoadjuvant therapy, Combination therapy) in Austria, France, Germany, New Zealand, South Korea, Spain, Spain, Taiwan, United Kingdom (IV)
  • 13 Nov 2025 Hoffmann-La Roche completes a phase I/II trial in Liver cancer (Combination therapy, Neoadjuvant therapy) in USA, Austria, France, Germany, New Zealand, South Korea, Spain, Taiwan, United Kingdom (IV) (NCT05908786)

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