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Tobemstomig - Hoffmann-La Roche

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Drug Profile

Tobemstomig - Hoffmann-La Roche

Alternative Names: Anti PD-1 anti LAG-3 bispecific antibody - Roche; Anti PD1 x LAG3; anti-PD-1/Anti-LAG-3 bispecific antibody RO7247669; anti-PD1/anti-LAG3 bispecific antibody RO7247669; PD1-LAG3 BsAb; RG-6139; RO-7247669

Latest Information Update: 08 Nov 2024

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At a glance

  • Originator Roche
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD223 antigen inhibitors; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Liver cancer; Malignant melanoma; Non-small cell lung cancer; Oesophageal cancer; Solid tumours; Triple negative breast cancer; Urogenital cancer

Most Recent Events

  • 08 Nov 2024 Discontinued - Phase-I for Solid tumours in Japan (IV)
  • 08 Nov 2024 Discontinued - Phase-I/II for Liver cancer (Combination therapy, Neoadjuvant therapy) in USA (IV)
  • 08 Nov 2024 Discontinued - Phase-I/II for Malignant melanoma (Combination therapy, In the elderly, Late-stage disease, In adults) in USA, Australia, France, Italy, Netherlands, Spain (IV)

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