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ION 839

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Drug Profile

ION 839

Alternative Names: AZD-2693; ION-839; IONIS-AZ6-2.5-LRx

Latest Information Update: 03 Dec 2024

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At a glance

  • Originator Ionis Pharmaceuticals
  • Developer AstraZeneca
  • Class Antisense oligonucleotides; Hepatoprotectants; Small molecules
  • Mechanism of Action Adiponutrin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-alcoholic steatohepatitis
  • Phase I Liver disorders
  • No development reported Metabolic disorders

Most Recent Events

  • 16 Sep 2024 AstraZeneca completes a phase I trial in Liver disorders in USA (NCT04142424)
  • 05 Jun 2024 Adverse events, pharmacokinetics and pharmacodynamics data from a phase I trial for Metabolic Disorders and Non-alcoholic Steatohepatitis presented at the European Association for the Study of the Liver Congress 2024 (EASL-2024)
  • 15 Feb 2024 ION 839 is still in a phase I trial for Non-alcoholic steatohepatitis in USA (SC) (NCT04483947)

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