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Sacituzumab tirumotecan - Klus Pharma/Merck & Co

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Drug Profile

Sacituzumab tirumotecan - Klus Pharma/Merck & Co

Alternative Names: MK-2870; sac-TMT; SKB-264

Latest Information Update: 03 Apr 2026

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At a glance

  • Originator Klus Pharma
  • Developer Klus Pharma; Merck & Co; Sichuan Kelun-Biotech Biopharmaceutical
  • Class Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed HER2 negative breast cancer; Non-small cell lung cancer; Triple negative breast cancer
  • Phase III Adenocarcinoma; Cervical cancer; Endometrial cancer; Urogenital cancer
  • Phase II Biliary cancer; Cancer; Colorectal cancer; Pancreatic cancer; Solid tumours
  • Phase I/II Bladder cancer; Gastrointestinal cancer

Most Recent Events

  • 30 Mar 2026 Phase-III clinical trials in Urogenital cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT07419295)
  • 18 Mar 2026 Efficacy data from a phase II OptiTROP-Lung03 trial in Solid tumours released by Sichuan Kelun-Biotech Biopharmaceutical
  • 06 Feb 2026 Launched for HER2-negative-breast-cancer (Metastatic disease, Second-line therapy or greater, Inoperable/Unresectable, Late-stage disease) in China (IV)

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