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Sacituzumab tirumotecan - Klus Pharma/Merck & Co

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Drug Profile

Sacituzumab tirumotecan - Klus Pharma/Merck & Co

Alternative Names: MK-2870; sac-TMT; SKB-264

Latest Information Update: 10 Aug 2026

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At a glance

  • Originator Klus Pharma
  • Developer Klus Pharma; Merck & Co; Sichuan Kelun-Biotech Biopharmaceutical
  • Class Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed HER2 negative breast cancer; Non-small cell lung cancer; Triple negative breast cancer
  • Phase III Adenocarcinoma; Cervical cancer; Endometrial cancer; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Urogenital cancer
  • Phase II Biliary cancer; Cancer; Colorectal cancer; Malignant thymoma; Pancreatic cancer; Solid tumours
  • Phase I/II Bladder cancer; Gastrointestinal cancer

Most Recent Events

  • 30 Jul 2026 Preregistration for Triple-negative-breast-cancer (First-line therapy, Metastatic disease, Recurrent) in China (IV)
  • 30 Jul 2026 Sacituzumab tirumotecan receives priority review status for Triple-negative-breast-cancer in China
  • 14 Jul 2026 Sichuan Kelun-Biotech Biopharmaceuticalplans to communicate with the CDE of NMPA of China based on the OptiTROP-Lung06 results

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