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Sacituzumab tirumotecan - Klus Pharma/Merck & Co

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Drug Profile

Sacituzumab tirumotecan - Klus Pharma/Merck & Co

Alternative Names: MK-2870; sac-TMT; SKB-264

Latest Information Update: 04 Jun 2025

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At a glance

  • Originator Klus Pharma
  • Developer Klus Pharma; Merck & Co; Sichuan Kelun-Biotech Biopharmaceutical
  • Class Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Triple negative breast cancer
  • Registered Non-small cell lung cancer
  • Phase III Adenocarcinoma; Cervical cancer; Endometrial cancer; HER2 negative breast cancer
  • Phase II Biliary cancer; Cancer; Colorectal cancer; Pancreatic cancer; Solid tumours
  • Phase I/II Bladder cancer; Gastrointestinal cancer; Urogenital cancer

Most Recent Events

  • 23 May 2025 Efficacy and adverse event data from the phase II OptiTROP-Lung01 trial in Non-small cell lung cancer released by Kelun Biotech Biopharmaceutical
  • 23 May 2025 Efficacy and adverse event data from the phase III OptiTROP-Lung03 trial in Non-small cell lung cancer released by Kelun Biotech Biopharmaceutical
  • 23 May 2025 Efficacy and adverse event data from the phase II OptiTROP-Breast05 trial in Breast cancer released by Kelun Biotech Biopharmaceutical

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