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Zotatifin - eFFECTOR Therapeutics

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Drug Profile

Zotatifin - eFFECTOR Therapeutics

Alternative Names: eFT 226

Latest Information Update: 27 Feb 2025

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At a glance

  • Originator eFFECTOR Therapeutics
  • Developer eFFECTOR Therapeutics; Quantitative Biosciences Institute
  • Class Amines; Antineoplastics; Antivirals; Benzonitrile; Cyclopentanes; Furans; Pyridines; Small molecules
  • Mechanism of Action Eukaryotic initiation factor-4A inhibitors; Virus replication inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Non-small cell lung cancer
  • No development reported COVID 2019 infections; Lymphoma

Most Recent Events

  • 07 Dec 2024 Pharmacodynamics data from preclinical studies presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 13 Sep 2024 Updated efficacy and adverse events data from a phase I/II trial in Solid tumours was presented at the 49th European Society for Medical Oncology Congress (ESMO-2024)
  • 28 Aug 2024 No recent reports of development identified for phase-I development in COVID-2019-infections(In the elderly, In adults) in USA (SC)

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