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Elenestinib - Blueprint Medicines

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Drug Profile

Elenestinib - Blueprint Medicines

Alternative Names: BLU-263

Latest Information Update: 23 Jul 2025

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At a glance

  • Originator Blueprint Medicines
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto-oncogene protein c-kit inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II/III Systemic mastocytosis
  • Phase I/II Haematological malignancies

Most Recent Events

  • 18 Jul 2025 Blueprint Medicines has been acquired by Sanofi
  • 10 Mar 2025 Blueprint Medicines terminates a phase I/II AZURE trial in Systemic mastocytosis (Combination therapy) in Norway, Spain, Netherlands, Germany, France, Belgium, USA (PO), due to alignment of strategic priorities (NCT05609942)
  • 30 Oct 2024 Blueprint Medicines plans a registration-enabling Part 2 of the HARBOR trial of elenestinib in Systemic mastocytosis in the second half of 2024

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