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Sonrotoclax - BeiGene

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Drug Profile

Sonrotoclax - BeiGene

Alternative Names: BGB-11417

Latest Information Update: 29 Nov 2024

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At a glance

  • Originator BeiGene
  • Developer Amgen; BeiGene
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto-oncogene protein c-bcl-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mantle-cell lymphoma; Acute myeloid leukaemia; Waldenstrom's macroglobulinaemia; Multiple myeloma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Chronic lymphocytic leukaemia
  • Phase II Mantle-cell lymphoma; Multiple myeloma; Richter's syndrome; Waldenstrom's macroglobulinaemia
  • Phase I/II Acute myeloid leukaemia; Myelodysplastic syndromes
  • No development reported B-cell lymphoma

Most Recent Events

  • 20 Nov 2024 BeiGene plans a phase I/II trial for Chronic lymphocytic leukaemia (First-line therapy) (PO), in December 2024 (NCT06697184)
  • 15 Oct 2024 BeiGene plans a phase II trial for Chronic lymphocytic leukaemia (Combination therapy, First-line therapy) (PO) in December 2024 (NCT06637501)
  • 13 Sep 2024 Efficacy and adverse events data from a phase I/II trial in Acute myeloid leukemia presented at the 29th Congress of the European Haematology Association (EHA-2024)

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