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Zorevunersen - Stoke Therapeutics

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Drug Profile

Zorevunersen - Stoke Therapeutics

Alternative Names: STK-001

Latest Information Update: 08 Sep 2025

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At a glance

  • Originator Stoke Therapeutics
  • Class Antiepileptic drugs; Antisense oligonucleotides; Neuroprotectants
  • Mechanism of Action Gene silencing; NAV1.1 voltage-gated sodium channel expression modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Dravet syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Dravet syndrome

Most Recent Events

  • 02 Sep 2025 Pooled efficacy and safety data from the phase I/IIa and open-label extension (OLE) studies in Dravet syndrome released by Stoke Therapeutics, and Biogen
  • 02 Sep 2025 Efficacy and adverse event data from phase I/IIa ADMIRAL trial in Dravet syndrome released by Stoke Therapeutics
  • 25 Aug 2025 Phase-III clinical trials in Dravet syndrome (In children, In adolescents) in European Union (Intrathecal)

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