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Zorevunersen - Stoke Therapeutics

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Drug Profile

Zorevunersen - Stoke Therapeutics

Alternative Names: STK-001

Latest Information Update: 14 Jul 2025

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At a glance

  • Originator Stoke Therapeutics
  • Class Antiepileptic drugs; Antisense oligonucleotides; Neuroprotectants
  • Mechanism of Action Gene silencing; NAV1.1 voltage-gated sodium channel expression stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Dravet syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Dravet syndrome

Most Recent Events

  • 10 Jul 2025 Efficacy data from a phase III EMPEROR trial in Dravet syndrome released by Biogen
  • 30 May 2025 Phase-III clinical trials in Dravet syndrome (In adolescents, In children) in USA (Intrathecal) (NCT06872125)
  • 18 Feb 2025 Stoke Therapeutics plans a phase III EMPEROR trial for Dravet syndrome (In children, In adolescents) in USA, Europe, and Japan (Intrathecal) in the second quarter of 2025

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